Sickle cell anemia belongs to a group of disorders known as sickle cell disease. They differ from one another based on the specific gene changes an individual has in the beta-globin gene; however, their symptoms can overlap. Other sickle cell diseases such as sickle-hemoglobin C and hemoglobin S-beta thalassemia tend to be milder conditions that sickle cell anemia. They can easily be differentiated from one another through simple blood tests such as hemoglobin electrophoresis.

