Krabbe disease is inherited in an autosomal recessive manner. This is one way a disorder or trait can be passed down through a family. Everyone has two copies of the GALC gene; one received from their father and one from their mother. Autosomal recessive inheritance means that a person receives a nonworking copy of the GALC gene from both parents. The parents have one working copy of the gene and one nonworking copy; they are carriers for Krabbe disease. Carriers do not develop symptoms of the disorder. If two people who are carriers have Krabbe disease, there is a 25% chance with each pregnancy that the child will have Krabbe disease and a 50% chance the child will also be a carrier for Krabbe disease. If you have a family member with Krabbe disease and you would like to know if you are a carrier, talk to your doctor or meet with a genetic counselor to discuss testing options.
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